Nausea, constipation or heartburn on Ozempic, Wegovy, Mounjaro or Zepbound? Dr. Rajiv Sharma and our dietitians help you feel better and stay on track. New patients are seen within 7 days, and no referral is needed.

Why GLP-1 medications upset your stomach

Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) slow how fast food leaves your stomach. That helps you feel full and eat less, and it also causes most side effects. They're usually worst in the first weeks and after each dose increase, then ease as your body adjusts.

Common side effects we treat

• Nausea and vomiting
• Constipation
• Diarrhea
• Bloating and sulfur burps
• Acid reflux and heartburn
• Feeling full after a few bites
• Stomach pain and cramping
• Fatigue from eating too little

When to get help right away

Severe stomach pain that spreads to your back, vomiting that won't stop, a swollen belly with no gas, yellow skin, or blood in your stool or vomit can be signs of pancreatitis, gallbladder disease or a blockage.

Call 911 or go to the nearest emergency room.

How we help

• A GI evaluation. We check whether symptoms are from the GLP-1 or something it uncovered, like GERD, IBS or SIBO.
• Testing if needed. Bloodwork, a gallbladder ultrasound, a stomach emptying study or an endoscopy.
• A plan to stay on track. Treatment for nausea, reflux and constipation, and dose timing changes with your prescriber.
• Dietitian support. Protein, smaller meals, water and fiber, planned around your medication.

Questions patients ask

How long do Ozempic and Wegovy side effects last?

They're usually worst in the first few weeks and after dose increases, then ease on a steady dose.

Are Mounjaro and Zepbound side effects the same?

They're similar. How strong they are depends on your dose and how fast it goes up.

What helps GLP-1 nausea?

Smaller meals, stopping when you first feel full and skipping greasy foods help many people.

Why am I so constipated on a GLP-1?

The medication slows your gut and you eat and drink less. Water, fiber and a bowel plan help.

Can a GLP-1 cause acid reflux or gastroparesis?

Yes. A slower stomach can cause reflux, and for a few people the slowing is severe. We can test for both.

Do I need a referral?

No. Some HMO and Medicare Advantage plans do, so we'll check your plan.

Feeling sick on your GLP-1? We can help.